An Avalon Waterways Central European cruise tour includes two nights in a Paris hotel; a fast ride on the TGV from Paris to Metz; a seven-day Avalon Tranquility cruise on the Moselle, Rhine, and Main Rivers from Trier, Germany to Nuremberg; and two nights in a Prague hotel. It is a marvelous cruise vacation, with two great cities and many small river towns to explore. And, there's all that wine! 
Cruising the Romantic Rhine on the Avalon Tranquility (c) Linda Garrison
Avalon very popular now with people based in the UK and of course river cruising is a fast growing sector in the cruise industry.